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K. R. Patel

Abstract

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V. G. Brahmbhatt ¹, N. M. Patel ¹, M. R. Patel ¹, K. R. Patel ¹

Affiliations
1 Department of Pharmaceutics, Shri B.M.Shah College of Pharmaceutical Education and Research, Modasa (S.K.), Gujarat - 383 315, IN

Abstract

In the present investigation solid dispersion of olanzapine has been prepared to improve its solubility. Further, using solid dispersion, mouth dissolving tablet was prepared to overcome the problem of swallowing. A Simplex Lattice design was applied using three factors, i.e. superdisintegrants like croscarmellose sodium(X₁) crospovidone(X₂), and sodium starch glycolate(X₃) in tablet formulation. Disintegration time and T₅₀ (Time required to 50% drug release) taken as responses. Solid dispersion showed significant enhancement in solubility of olanzapine. For mouth dissolving tablet, batch containing 5% croscarmellose sodium alone had minimum disintegration time (44 sec.) and faster drug release (T₅₀: 40 sec) compared to other batches.

Keywords

Olanzapine, Solid Dispersion, Solubility, Mouth Dissolving Tablet, Disintegration.

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Beena Bhatia ¹, K. R. Patel ¹, R. P. Tripathi ¹, S. Layek ², H. C. Verma ²

Affiliations
1 Depatment of Physics, Jai Narain Vyas University, Jodhpur 342 001, IN
2 Department of Physics, Indian Institute of Technology, Kanpur 208 016, IN

Abstract

In the present communication, we show that Mössbauer spectra of cumulate eucrites are characteristically different from those of non-cumulate eucrites. In cumulate eucrites, iron occupies only one site, i.e. the M2 site in pyroxene crystal lattice, while it is distributed in both M1 and M2 sites in non-cumulate eucrites. We discuss the importance of asymmetric doublet observed in the Mössbauer spectrum of cumulate body, especially in Vissannapeta cumulate eucrite (fallen in Andhra Pradesh, India), where an appreciable asymmetry was observed. The Mössbauer parameters of diogenite almost exactly replicate those of cumulate eucrites, suggesting that they originate from the same magma ocean. Howardites which are mixed eucrites and diogenites, show iron mineralogy which is different from what one would expect from a physical mixture model. The possible reasons for this difference are also discussed.

Keywords

Cumulate and Non-Cumulate Eucrites, HED Bodies, Mossbauer Spectroscopy, Meteorites.

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